Caudal Epidural Catheterization in Pediatric Renal Transplant: Effect on Hemodynamics and Pain After Surgery

Cairo University (CU)

Status: Completed

Conditions: Renal Failure

Treatments: Drug: Bupivacaine; Device: B-Braun, Perifix® ONE Paed, Germany; Drug: Propofol; Drug: Pethidine; Drug: Fentanyl

Study type: Interventional

Funder types: Other

Identifiers

NCT02037802

SMS2014-1

Details and patient eligibility

About

pain control in pediatric renal transplant is a major concern. the main goal during anesthesia of renal transplant in pediatrics is to maintain hemodynamics in a range close to that of the adult donor. epidural analgesia is thought to be very effective in pain control. this study emphasises the ease of application of epidural catheter via the caudal route to the lower thoracic level; avoiding possible complications that may arise from lumbar or thoracic routes, and its effects on hemodynamics when using analgesic doses of local anesthetics and narcotics.

Enrollment: 60 patients

Sex: All

Ages: 3 to 12 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 3-12 years
• end stage renal disease
• no known allergy to bupivacaine
• both sexes

Exclusion criteria

• known allergy to bupivacaine
• inflammation at caudal area
• spinal cord deformity

Trial design

60 participants in 2 patient groups

caudal epidural catheterization group

Active Comparator group

Description:

30 patients received continuous intra and post-operative caudal epidural infusion of bupivacaine 0.125% with fentanyl (2 microgram/ml) over 24 hours

Treatment:

Drug: Bupivacaine

Drug: Propofol

Drug: Fentanyl

Drug: Pethidine

Device: B-Braun, Perifix® ONE Paed, Germany

control group

Sham Comparator group

Description:

30 patients didn't receive caudal epidural analgesia

Treatment:

Drug: Propofol

Drug: Fentanyl

Drug: Pethidine