Causal Associations Between Allergic Rhinitis and Asthma

Zhibin Xu

Status: Completed

Conditions: Asthma; Allergic Rhinitis

Treatments: Other: Mendelian Randomization

Study type: Observational

Funder types: Other

Identifiers

NCT06668974

GS-002

Details and patient eligibility

About

This study investigates the causal relationship between allergic rhinitis and asthma using a bidirectional two-sample Mendelian randomization approach. Genetic data were derived from UK Biobank for allergic rhinitis and from Finnish biobank for asthma. This analysis aims to clarify the potential causal link between these two conditions.

Full description

This observational study utilizes a bidirectional two-sample Mendelian randomization (MR) analysis to examine the causal association between allergic rhinitis and asthma. The genetic data for allergic rhinitis were obtained from the UK Biobank, encompassing 18,934 cases and 64,595 controls, while asthma data were derived from a Finnish biobank, including 20,629 cases and 135,449 controls. The Mendelian randomization analysis was performed using inverse-variance weighting (IVW), Mendelian randomization-Egger (MR-Egger), and weighted median methods to ensure robust causal inference. Additional tests, such as Cochrane's Q test and Mendelian randomization pleiotropy residual sum and outlier (MR-PRESSO), were applied to assess heterogeneity and pleiotropy, enhancing the reliability of the findings. The results are expected to provide insights into the bidirectional causal relationship between allergic rhinitis and asthma, potentially informing future prevention and treatment strategies.

Enrollment: 239,607 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Individuals diagnosed with allergic rhinitis or asthma.
• Availability of genetic data in the UK Biobank or Finnish biobank.

Exclusion criteria

• Individuals without genetic data.
• Participants with incomplete phenotype or genotype data.

Trial design

239,607 participants in 2 patient groups

Allergic Rhinitis Cohort

Description:

This cohort consists of individuals with allergic rhinitis and a control group from the UK Biobank database, including 18,934 cases of allergic rhinitis and 64,595 controls. Genetic data were used to explore causal relationships with asthma.

Treatment:

Other: Mendelian Randomization

Asthma Cohort

Description:

This cohort includes individuals with asthma and a control group from the Finnish biobank database, consisting of 20,629 cases of asthma and 135,449 controls. Genetic data were analyzed to examine causal associations with allergic rhinitis.

Treatment:

Other: Mendelian Randomization