CB1R in Synthetic Psychoactive Cannabinoids (CB1R in Spice)

Yale University

Status: Active, not recruiting

Conditions: Drug Dependence

Treatments: Other: [11-C]OMAR

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT03539575

1R21DA041580-01A1 (U.S. NIH Grant/Contract)

1308012514A

Details and patient eligibility

About

The purpose of this research study is to determine whether the CB1R availability is lower in synthetic psychoactive cannabinoid subjects using the most widely available synthetic psychoactive cannabinoids at the time the study is initiated.

Enrollment: 15 estimated patients

Sex: All

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion:

• Able to provide written consent
• Age 18-55
• Current Synthetic Psychoactive Cannabinoids consumption

Exclusion:

• MRI metal exclusions and claustrophobia
• Education completed is less than 12 years

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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15 participants in 1 patient group

Synthetic Psychoactive Cannabinoid Users

Other group

Description:

Synthetic Psychoactive Cannabinoid dependent subjects who are frequent spice/K2 users will receive the radiotracer \[11-C\]OMAR.

Treatment:

Other: [11-C]OMAR