CBT-1® in Combination With Doxorubicin in Patients With Metastatic, Unresectable Sarcomas Who Previously Progressed on Doxorubicin

CBA Associates

Status and phase

Unknown

Phase 1

Conditions

Sarcoma

Treatments

Drug: CBT-1®

Study type

Interventional

Funder types

Industry

Identifiers

NCT03002805

STS-1701

Details and patient eligibility

About

This study evaluates the combination of CBT-1® and doxorubicin for the treatment of metastatic, unresectable sarcoma in patients who have progressed after treatment with 150mg/m2 or less of doxorubicin. Participants will receive CBT-1® on days 1-7 of each 21-day cycle, as well as doxorubicin on days 5 and 6.

Enrollment

46 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age ≥ 18 years
Locally advanced or metastatic, unresectable sarcoma that has progressed after treatment with 150 mg/m2 or less of doxorubicin or anthracycline equivalent
Measurable disease by RECIST 1.1
ECOG performance status of ≤ 1
Life expectancy of > 3 months
Able to swallow pills
Adequate bone marrow and organ function as defined as:
Hemoglobin > 9 g/dl
Absolute neutrophil count ≥ 1,500/mcL
Platelets ≥ 100,000/mcL
Total bilirubin < 1.5 X ULN
AST(SGOT)/ALT(SGPT) ≤3 X ULN (including patients with liver metastases)
Creatinine <1.5 X ULN
Cardiac ejection fraction >50% (by echocardiogram or MUGA) within 15 days of enrollment
Women of childbearing potential must have a negative serum or urine pregnancy test within 7 days prior to enrollment.
Participants must be willing and able to comply with the study scheduled visits, laboratory tests, and other procedures outlined in the protocol.
Pre-menopausal women must have a negative pregnancy test before study entry. Both women and men must agree to use a medically acceptable method of contraception throughout the treatment period and for at least six weeks after treatment discontinuation. Acceptable methods of contraception include intrauterine device (IUD), oral contraceptive, subdermal implant, double barrier and/or complete abstinence (non-periodic).
Washout period prior to Day 1 Cycle 1:
3 weeks since last chemotherapy or therapeutic radiation therapy
4 weeks or 3 half-lives since prior antibody-based therapy, whichever is shorter
2 weeks since any oral anti-neoplastic or oral investigational agent
Resolution of treatment-related toxicity to < grade 1; alopecia and cutaneous toxicity are allowed < grade 2
>1 week since palliative RT
Ability to understand and the willingness to sign a written informed consent document

Exclusion criteria

Prior exposure to CBT-1
Previously untreated sarcomas
Low-grade sarcomas as well as alveolar soft parts sarcoma, clear cell sarcoma, extraskeletal myxoid chondrosarcoma, well-differentiated liposarcoma, gastrointestinal stromal tumor, chordoma
Participants receiving other investigational agents
Participants with known uncontrolled brain metastases
Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, chronic indwelling drains, history of interstitial pneumonitis or pulmonary fibrosis or psychiatric illness/social situations that would limit compliance with study requirements
Actively breastfeeding women unless it is interrupted during treatment and at least 6 weeks after treatment discontinuation