CD Patients Immune Status Evaluation

Zhejiang University

Status: Completed

Conditions: Severe Crohn's Diease

Treatments: Other: colonic tissue biopsy

Study type: Observational

Funder types: Other

Identifiers

NCT04135482

ZJU-JX-CD1

Details and patient eligibility

About

Using single cell sequencing method to evaluate and compare the immune status of patients with severe CD.

Enrollment: 10 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria: 1, Patients with severe CD（CDAI>16,SES-CD>19） 2, Patients have no previous any drug therapy targeting CD or just received treatment of 5-ASA - Exclusion Criteria: 1, patients have previous treatment of prednisone, immunosuppressive agents such as azathioprine and biologic agents such as infliximab 2, patients were diagnozed as mild-moderate CD 3, patients have other immune disordered diseases such as SLE, PBC, AIH, PSC, sjogren syndrome, ulcerative colitis, and so on.

Trial design

10 participants in 1 patient group

CD

Description:

patients with severe crohn's disease

Treatment:

Other: colonic tissue biopsy