Cedar Honey in Oral Lichen Planus

Mashhad University of Medical Sciences

Status and phase: Completed; Phase 2; Phase 1

Conditions: Erosive and Atrophic Oral Lichen Planus

Treatments: Drug: orally administered cedar honey

Study type: Interventional

Funder types: Other

Identifiers

NCT01974414

900166

Details and patient eligibility

About

The study aimed to evaluate the effect of cedar honey in treatment of erosive and atrophic oral lichen planus ( a common oral problem).

Enrollment: 36 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. clinically and histopathologically confirmed oral lichen planus without dysplasia in histopathologic evaluation
2. Severity of pain≥2 (VAS score)
3. Severity of lesions≥2 (tong prasom criteria)
4. absence of any treatment in the last month
5. absence of kidney or liver diseases( due to systemic administration of fluconazole to both groups)

Exclusion criteria

1. evidence of lichenoid reaction in clinical or histopathologic assessment
2. loss of follow up
3. pregnant patients
4. diabetic patients
5. any other mucosal disease
6. any severe systemic disease
7. patients who refuse doctor's advice
8. any unexpected adverse effect of honey

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

36 participants in 2 patient groups

cedar honey

Active Comparator group

Description:

The two study groups were provided with standard treatment(dexamethasone and Fluconazole).The Case group(A) received cedar honey, 20 ml 3 times daily by swish and swallow technique, in addition to the standard treatment .

Treatment:

Drug: orally administered cedar honey

control group

No Intervention group

Description:

the control group (B) only received standard treatment(Dexametazone and Fluconazole).