Cefazolin Antibiotic Prophylaxis in Ventricular Shunt Surgery: Determination of Cerebrospinal Fluid Concentration During Valve Implantation (CC -PIV)

University Hospital, Strasbourg, France

Status: Not yet enrolling

Conditions: Hydrocephaly; CSF Shunts; Antibiotic Prophylaxis

Treatments: Other: Cefazolin antibiotic prophylaxis

Study type: Interventional

Funder types: Other

Identifiers

NCT07067736

9720

Details and patient eligibility

About

The objective is to determine the concentration of cefazolin in the cerebrospinal fluid after a recommended antiobiotic prophylaxis by 2g of cefazolin. Our main hypothesis is that the concentration is insufficient to protect the valve from infections.

The secondary objective is to compare our results to known pharmacokinetic models of cefazolin diffusion in the literature. If differences are found we would like to search clinical features that could explain it.

Enrollment: 15 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Age >18 years and programmed for a ventricular shunt surgery at the Hautepierre university hospital in Strasbourg.

Exclusion criteria

• Age <18 years old
• Pregnant women
• Infected patients
• Known cefazolin allergy
• Other molecule used for the antibiotic prophylaxis
• Guardianship or conservatorship
• Patients under curative antibiotherapy
• Non sterile pre operative CSF
• Refusal to participate

Trial design

Primary purpose: Health Services Research

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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15 participants in 1 patient group

Cefazolin antibiotic prophylaxis in ventricular shunt surgery

Experimental group

Treatment:

Other: Cefazolin antibiotic prophylaxis