Cell-free DNA in Acute Stroke (CANTO)

University Hospital Basel

Status: Enrolling

Conditions: Stroke

Study type: Observational

Funder types: Other

Identifiers

NCT06928675

2025-00235 ko24grosse2;

Details and patient eligibility

About

Cell-free DNA (cfDNA) is an important pro-inflammatory and prothrombotic mediator. With this study the investigators aim to gain new insights into the role of cfDNA in stroke and to perform a combined analysis of cfDNA in the hyperacute phase of the disease using blood and thrombus analyses. The main objectives are to analyse cfDNA in different stroke etiologies, to investigate the relationship between cfDNA and important procedural factors such as secondary embolisation and reperfusion outcomes, to analyse the correlation between blood and thrombus content of cfDNA and to investigate the specific source of cfDNA in distinct stroke subtypes.

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Acute ischemic stroke due to large vessel occlusion (LVO) who require mechanical thrombectomy (detected in CT-Scan or MRI-Scan)
• 18 years of age

Exclusion criteria

• Patients currently undergoing immunological therapies.
• Patients with immunological diseases
• Patients with systemic infections at the time of admission