Cell-free Fetal DNA Concentration in Cases of Abnormal Placental Invasion .

Ain Shams Maternity Hospital

Status: Unknown

Conditions: Placenta Percreta; Placenta Accreta; Placenta Previa; Placenta Increta

Treatments: Diagnostic Test: Maternal plasma cell free fetal DNA levels

Study type: Observational

Funder types: Other

Identifiers

NCT03638024

Cell free fetal DNA

Details and patient eligibility

About

Cell free fetal DNA might predict abnormal placental invasion

Full description

This study aims to evaluate whether measurement of cell-free fetal DNA in the maternal plasma can be predictive of abnormal invasion in cases of placenta previa.

Enrollment: 50 estimated patients

Sex: Female

Ages: 20 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Maternal age range from 20-40 years old.
2. Parity: para 1- para 5.
3. Body mass index range from 18-25 kg/m2.
4. Singleton pregnancy carrying male fetuses.
5. Gestational age range from 28-34 weeks.

Exclusion criteria

1. Multifetal pregnancy.

2. Hypertension, preterm labor and intrauterine growth restriction.

3. Patients taking a tocolytic agent or those with uterine bleeding at or after blood sampling.

   • Since these complications may increase the level of cell-free fetal DNA.

4. Accidental hemorrhage.

Trial design

50 participants in 2 patient groups

Study group

Description:

Maternal plasma cell free fetal DNA levels will be measured in 25 women with one or more previous cesarean section and placenta previa anterior only or with ultrasound finding suggestive of placental adhesion or invasion (accreta , increta or percreta).

Treatment:

Diagnostic Test: Maternal plasma cell free fetal DNA levels

Control group

Description:

Maternal plasma cell free fetal DNA levels will be measured in 25 matched control with normally situated placenta without ultrasound finding suggestive of placental adhesion or invasion.

Treatment:

Diagnostic Test: Maternal plasma cell free fetal DNA levels