Cell Therapy Associated With Endobronchial Valve (CEL&VAL)

Hospital de Clinicas de Porto Alegre

Status and phase

Enrolling

Phase 3

Phase 2

Conditions

Chronic Obstructive Pulmonary Disease Severe

Treatments

Device: Zephyr Endobronchial Valve

Biological: Marrow-derived mesenchymal stromal cell

Study type

Interventional

Funder types

Other

Identifiers

NCT04018729

2018-0327

Details and patient eligibility

About

Chronic obstructive pulmonary disease (COPD) is one of the most common diseases worldwide and is considered a public health problem. The World Health Organization estimates that about 210 million people have COPD. Disease-related mortality is more than 3 million, representing 5% of all deaths, 90% of this mortality being concentrated in middle- and low-income countries. COPD can be subdivided into chronic bronchitis and emphysema. Emphysema, the focus of this project, is histologically defined by the permanent increase of the distal air spaces to the terminal bronchioles associated with the destruction of the alveolar septa in the lung. Approximately two-thirds of adult men and a quarter of women (most without dysfunction) will have well-defined emphysema, but often of limited extent.

Mesenchymal stem cells (MSCs) have anti-inflammatory, anti-fibrotic, microbicide and repair potential. Regarding COPD, several authors have concentrated efforts in the investigation of the relationship between the severity of the condition and the various sources of adult stem cells. Apparently the lungs have a high chemotactic effect in relation to adult stem cells, since several studies have evidenced a high implantation (6-20%) of stem cells derived from bone marrow, administered systemically, in the pulmonary tissue of receptors. Therefore, MSCs has been tested in different lung diseases have no effective treatment, such as pulmonary fibrosis, acute respiratory distress syndrome, asthma, COPD positive results, such as reduction of fibrosis, reduction of proliferation inflammatory cells and cytokines, reduction of infectious processes and recovery of the histological changes caused by pulmonary emphysema.

Based on these findings, the purpose of this project is to evaluate the safety and efficacy of endoscopic administration of bone marrow stem cells in patients with severe homogeneous emphysema and evaluating the feasibility, efficacy and safety of this procedure.

Enrollment

34 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Diagnosis of severe heterogeneous pulmonary emphysema (at least 10% of total lung parenchyma or 25% of target lobe with density < -950HU);
Heterogeneity> 15pp (difference of at least 15 percentage points of lung parenchyma with density greater than -950HU between the treated lobe(s) and the remaining lung on the same side)
Estimates of low or non-existent collateral ventilation (fissure integrity> 95% measured by VIDA Diagnostics or collateral ventilation measured by negative Chartis® System)
Total lung capacity> 100% of predicted
Residual volume> 175% of predicted
FEV1 <50% of predicted post-bronchodilator
DLCO (diffusing capacity of the lungs for carbon monoxide) <45% of predicted post-bronchodilator
Body Mass Index (BMI) Greater than 18Kg/m2 and less than 35Kg/m2.
Optimized clinical treatment
Daily physical activities limitation
Possibility of pulmonary rehabilitation
Preserved ventricular function (LVEF> 40%)
Cessation of smoking ≥ 4 months
Dyspnea MMRC ≥ 2

Exclusion criteria

Homogeneous emphysema
Estimated collateral ventilation observed on CT scanned by VIDA vision software (VIDA vision®, VIDA Diagnostics, Iowa-USA) - Fissure integrity on target lobe less than 75%.
Use of continuous systemic corticosteroid therapy> 20mg QD (quaque die, once a day) of prednisone (or equivalent)
Active lung or extra pulmonary infection
Coronary heart disease and/or severe ventricular dysfunction
Significant renal or hepatic disease
Immunosuppressive disease
Rheumatologic or orthopedic disease limiting physical capacity;
Cognitive inability to understand study procedures;
Impression by clinical research investigators with a lifespan of less than a year1;
Active smoking
Malignant neoplasia with estimated prognosis of survival <2 years
Psychosocial problems
Pregnancy