Centella Asiatica in Older Adults

National University of Natural Medicine (NUNM)

Status: Not yet enrolling

Conditions: Endothelial Dysfunction

Treatments: Dietary Supplement: Centella Asiatica; Dietary Supplement: Placebo Comparator

Study type: Interventional

Funder types: Other

Identifiers

NCT06472791

BZCA

Details and patient eligibility

About

The purpose of this study is to determine the effects of a dietary supplement containing centella asiatica on on vascular endothelial function in older adults.

Enrollment: 30 estimated patients

Sex: All

Ages: 50 to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

● Age 50 through 85, male or female

• Sufficient proficiency in English to understand study purpose and directions
• Willing and able to give informed consent
• Able to follow protocol and attend visits

Exclusion criteria

• History of myocardial infarction, known coronary or carotid disease, or heart failure
• History of stroke, Parkinson's disease, dementia, or other major CNS disorders
• History of hepatic disease (e.g. hepatitis, cirrhosis)
• Recent/recurring history of severe life-threatening medical conditions (e.g. cancer, except non-melanoma skin cancers)
• Active major infectious disease (e.g. pneumonia)
• Heavy alcohol use (15 drinks or more per week for men or 8 drinks or more per week for women) or substance use disorder
• Current use of any medication typically used to treat hypertension or lower blood pressure (e.g. beta-blockers, ACE inhibitors)
• Current use of any medication typically used to prevent the coagulation of blood (e.g. warfarin (Coumadin))
• Chronic NSAID use (>3 times a week for more than 3 months)
• Current use of any medication or supplement typically used as a sedative (e.g. zolpidem (Ambien), benzodiazepines (Valium, Xanax), valerian root)
• Dietary supplements for improving nitric-oxide synthesis (e.g. L-arginine, L-citrulline)
• Current use of any medication typically used to control hypoglycemia (e.g. biguanides (Metformin))
• Current use of any medication typically used for erectile dysfunction (e.g. sildenafil (Viagra), tadalafil (Cialis))
• Pregnant, nursing, or planning a pregnancy within the next 6 weeks
• Open skin rashes and sores that may interfere with the placement of sensors

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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30 participants in 2 patient groups, including a placebo group

Centlla Asiatica

Experimental group

Description:

250 mg/day (1 capsules) for week 1. 500 mg/day (2 capsules) for week 2. 750 mg/day (3 capsules) for week 3. 1000 mg/ day (4 capsules) for week 4.

Treatment:

Dietary Supplement: Centella Asiatica

Placebo

Placebo Comparator group

Description:

Matched number of capsules per week. Capsules will contain microcrystalline cellulose.

Treatment:

Dietary Supplement: Placebo Comparator