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Centella Asiatica in Older Adults

National University of Natural Medicine (NUNM) logo

National University of Natural Medicine (NUNM)

Status

Not yet enrolling

Conditions

Endothelial Dysfunction

Treatments

Dietary Supplement: Centella Asiatica
Dietary Supplement: Placebo Comparator

Study type

Interventional

Funder types

Other

Identifiers

Details and patient eligibility

About

The purpose of this study is to determine the effects of a dietary supplement containing centella asiatica on on vascular endothelial function in older adults.

Enrollment

30 estimated patients

Sex

All

Ages

50 to 85 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

● Age 50 through 85, male or female

  • Sufficient proficiency in English to understand study purpose and directions
  • Willing and able to give informed consent
  • Able to follow protocol and attend visits

Exclusion criteria

  • History of myocardial infarction, known coronary or carotid disease, or heart failure
  • History of stroke, Parkinson's disease, dementia, or other major CNS disorders
  • History of hepatic disease (e.g. hepatitis, cirrhosis)
  • Recent/recurring history of severe life-threatening medical conditions (e.g. cancer, except non-melanoma skin cancers)
  • Active major infectious disease (e.g. pneumonia)
  • Heavy alcohol use (15 drinks or more per week for men or 8 drinks or more per week for women) or substance use disorder
  • Current use of any medication typically used to treat hypertension or lower blood pressure (e.g. beta-blockers, ACE inhibitors)
  • Current use of any medication typically used to prevent the coagulation of blood (e.g. warfarin (Coumadin))
  • Chronic NSAID use (>3 times a week for more than 3 months)
  • Current use of any medication or supplement typically used as a sedative (e.g. zolpidem (Ambien), benzodiazepines (Valium, Xanax), valerian root)
  • Dietary supplements for improving nitric-oxide synthesis (e.g. L-arginine, L-citrulline)
  • Current use of any medication typically used to control hypoglycemia (e.g. biguanides (Metformin))
  • Current use of any medication typically used for erectile dysfunction (e.g. sildenafil (Viagra), tadalafil (Cialis))
  • Pregnant, nursing, or planning a pregnancy within the next 6 weeks
  • Open skin rashes and sores that may interfere with the placement of sensors

Trial design

Primary purpose

Other

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Quadruple Blind

30 participants in 2 patient groups, including a placebo group

Centlla Asiatica
Experimental group
Description:
250 mg/day (1 capsules) for week 1. 500 mg/day (2 capsules) for week 2. 750 mg/day (3 capsules) for week 3. 1000 mg/ day (4 capsules) for week 4.
Treatment:
Dietary Supplement: Centella Asiatica
Placebo
Placebo Comparator group
Description:
Matched number of capsules per week. Capsules will contain microcrystalline cellulose.
Treatment:
Dietary Supplement: Placebo Comparator

Trial contacts and locations

1

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Central trial contact

Anders Gundersen, MS; Benjamin Zimmerman, PhD

Data sourced from clinicaltrials.gov

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