Central Blood Pressure and Pulse Wave Velocity in Kidney Transplant Recipients

Children's National

Status: Active, not recruiting

Conditions: End Stage Renal Disease

Treatments: Other: there is no intervention

Study type: Observational

Funder types: Other

Identifiers

NCT04212143

Pro00013491

Details and patient eligibility

About

An observational cohort study will be conducted to non-invasively investigate central blood pressure and pulse wave velocity in children with kidney disease and controls. Using an oscillometric monitor, the investigators aim to non-invasively obtain the central blood pressure and pulse wave velocity (PWV), or arterial stiffness, of children with kidney disease. The investigators will also enroll age- and race-matched healthy controls and measure the same parameters for comparison. In addition, the investigators will measure PWV by standard arterial tonometry method in a subset of patients.

Full description

The specific aims of the study are as follows:

1. Using an oscillometric blood pressure monitor, the investigators aim to non-invasively obtain the central blood pressure and pulse wave velocity (PWV), or arterial stiffness, of children with kidney disease.
2. Measure oscillometric central blood pressure and PWV in age and race matched healthy children.
3. Measure PWV by standard arterial tonometry method in a subset of patients, and compare these measurements to the PWV measured using the oscillometric device.
4. Measure body composition of patients and controls (Body Mass Index, Waist-to-Height ratio, %body fat, and mid-arm muscle circumference) to see how this relates to central blood pressure and PWV.

Enrollment: 150 estimated patients

Sex: All

Ages: 3 to 21 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• kidney transplant recipients who are at least 6 months post-transplant
• healthy children matched for age sex and race

Exclusion criteria

• age less than 3 years

Trial design

150 participants in 2 patient groups

children with kidney disease

Description:

Kidney transplant recipients age 3 to 21 years

Treatment:

Other: there is no intervention

healthy control

Description:

Healthy children age 3 to 21 years

Treatment:

Other: there is no intervention