Central Haemodynamics and Pacing for AV Block (PACE-CCQ)

University of Tartu

Status

Enrolling

Conditions

Pacing Therapy

Atrioventricular Block

Conduction System Pacing

Right Ventricular Pacing

Treatments

Device: Conduction system pacing

Device: Right ventricular pacing

Study type

Interventional

Funder types

Other

Identifiers

NCT07276490

405/M-27

Details and patient eligibility

About

A randomized, single-blind study comparing two pacing strategies in patients with atrioventricular block requiring permanent pacemaker implantation. This trial evaluates the impact of conduction system pacing (left bundle branch area pacing) versus standard right ventricular pacing on central hemodynamics, cardiac function, and patient quality of life over 12 months. The study will enroll 124 patients from two Estonian tertiary hospitals and measure central systolic arterial pressure as the primary outcome, with secondary assessments of arterial stiffness, echocardiographic parameters, electrical activation patterns, and quality of life scores.

Enrollment

124 estimated patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age 18-80 years
Diagnosis of atrioventricular block
Expected survival >1 year

Exclusion criteria

Reduced left ventricular ejection fraction (EF <45%)
Expected ventricular pacing burden <20%
Inter-arm systolic blood pressure difference >15 mmHg
Percutaneous coronary intervention or coronary artery bypass surgery within the last 30 days
Secondary hypertension
Orthostatic hypotension
Clinically significant valvular heart disease
Congenital heart disease
Pulse wave analysis or pulse wave velocity measurement cannot be reliably performed
Pregnancy or breastfeeding
Withdrawal of consent by the subject
Loss of contact during the study