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Central Motor Mechanisms in AIS Via HD-sEMG, EEG and Neuromuscular Coupling Analysis

T

The First Affiliated Hospital of Zhejiang Chinese Medical University

Status

Enrolling

Conditions

Adolescent Idiopathic Scoliosis

Treatments

Procedure: Tuina (Massage) Therapy

Study type

Observational

Funder types

Other

Identifiers

NCT06758115
2024-KL-504-02

Details and patient eligibility

About

  1. Verifying the Motor Control Effects of Spinal Manipulation on AIS Using outpatient and inpatient AIS patients from our department as the study subjects, standardized spinal manipulation treatment is applied. The efficacy is evaluated through a combination of clinical outcome measures, HD-EMG for paraspinal muscle function assessment, and Pro-Kin balance system for trunk stability analysis. This establishes an AIS efficacy platform to further clarify the effectiveness of spinal manipulation in motor control regulation of AIS.
  2. Investigating the Central Motor Network's Response to Spinal Manipulation in AIS Utilizing high-density sEMG-EEG technology, synchronized brain and muscle electrical signals are collected before and after treatment. By employing a neuromuscular synchronization and coupling analysis approach that integrates linear and nonlinear methods, the characteristic indices of information interaction between the central system and muscles are identified. This further explores the motor control and response characteristics of the muscle-cortex network to spinal manipulation in AIS.

Enrollment

40 estimated patients

Sex

All

Ages

10 to 18 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  1. Patients aged ≥10 years;
  2. Risser sign grade 0-3;
  3. Cobb angle between 10° and 40°;
  4. No prior treatment;
  5. Female patients within 1 year after menarche or before menstruation;
  6. The patient's guardian signs the informed consent form for treatment.

Exclusion criteria

  1. Those who do not meet the diagnostic criteria for AIS or inclusion criteria;
  2. Patients with severe primary diseases such as cardiovascular, cerebrovascular, liver, kidney, and hematopoietic system disorders, or those with mental illnesses;
  3. Patients with thrombocytopenia, coagulation disorders, or a tendency to bleed;
  4. Patients who are afraid of the treatment and cannot tolerate it;
  5. Those who have already received other treatments that may affect the study's outcome measures.

Trial design

40 participants in 2 patient groups

AIS
Treatment:
Procedure: Tuina (Massage) Therapy
Healthy Control Group
Treatment:
Procedure: Tuina (Massage) Therapy

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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