Central Sensitization in Chronic Whiplash Patients

University of Castilla-La Mancha

Status: Unknown

Conditions: Chronic Pain

Treatments: Procedure: Conditioned Pain Modulation; Radiation: Spectroscopy; Other: Questionnaires

Study type: Observational

Funder types: Other

Identifiers

NCT03005691

GFSM-HNP

Details and patient eligibility

About

The purpose of this study is to determine whether the metabolite concentrations within the anterior cingulate cortex and periaqueductal gray matter predict the intensity and interference of neuropathic pain after the development of chronic whiplash syndrome.

Full description

Persistent chronic pain is a common symptom of whiplash leading to reduced quality of life. Little information is available regarding changes in brain processing areas and change in central sensitization to noxious input during the chronic phase of whiplash. Metabolite concentrations in the anterior cingulate cortex and periaqueductal gray matter may be predictors of neuropathic pain and these changes may explain the development of central sensitization in people with chronic whiplash.

Until now, there is not any study that show this approach.

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Whiplash syndrome
• Chronic pain
• Age between 18 to 65 years
• 4 months to 2 years after the whiplash syndrome

Exclusion criteria

• Neurological disease
• Claustrophobia

Trial design

30 participants in 3 patient groups

Whiplash-Pain

Description:

Subjects with chronic whiplash syndrome and pain. The inclusion criteria for pain include the presence of daily pain during the previous 8 weeks. Specifically, pain will be diagnosed based on the pain intensity measured on the 0 to 10 numerical rating scale. The minimum will be 2 points. Subjects will be recruited between the 4 months until 2 years after the whiplash.

Treatment:

Procedure: Conditioned Pain Modulation

Radiation: Spectroscopy

Other: Questionnaires

Whiplash-no Pain

Description:

Subjects with chronic whiplash syndrome and pain. The inclusion criteria for pain include the ausence of daily pain during the previous 8 weeks. Specifically, pain will be diagnosed based on the pain intensity measured on the 0 to 10 numerical rating scale. The maximun will be 2 points. Subjects will be recruited between the 4 months until 2 years after the whiplash.

Treatment:

Procedure: Conditioned Pain Modulation

Radiation: Spectroscopy

Other: Questionnaires

Non-injured

Description:

Subjects without whiplash syndrome. The inclusion criteria are defined as a absence of previous or actual symptoms or signs of neck pain.

Treatment:

Procedure: Conditioned Pain Modulation

Radiation: Spectroscopy

Other: Questionnaires