Central Venous Pressure (CVP) Changes do Not Predict Preload Unresponsiveness

Hopital Antoine Beclere

Status: Unknown

Conditions: Cardiovascular Shock

Treatments: Diagnostic Test: preload responsiveness

Study type: Observational

Funder types: Other

Identifiers

NCT03753672

2017-A03578-45

Details and patient eligibility

About

Passive leg raising (PLR) is routinely used to predict preload responsiveness in critically ill patients. However, real-time measurements of cardiac output are required to assess its effects. Some authors have suggested that in fluid non-responders, central venous pressure (CVP) increased markedly. By analogy with the CVP rules proposed by Weill et al to assess a fluid challenge, it has been hypothesized that an increase in CVP ≥ 5 mmHg during PLR can predict preload unresponsiveness.

Objective Investigation of whether an increase in CVP ≥ 5 mmHg during PLR predict preload unresponsiveness diagnosed by the absence of increase in velocity-time integral (VTI) of the flow in the left ventricular outflow tract by more than 10% (4).

Methods Critically ill patients with a central venous catheter in place and for whom the physician decided to test preload responsiveness by PLR were prospectively included. Transthoracic echocardiography was performed to obtain VTI. The CVP and VTI were measured before and during PLR.

Enrollment: 45 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• ADULTS
• Patients presenting with shock or other signs of circulatory failure (tachycardia, oliguria)
• Need for the physician to test preload responsiveness
• Patients already equipped by a central venous catheter for the measurement of CVP

Exclusion criteria

• patients<18 years old
• pregnancy
• instaility justifying rapid increase in cathecolamines

Trial design

45 participants in 2 patient groups

preload responsive

Description:

defined as an increase in Velocity time integral of the sub-aortic flow greater or equal to 10%

Treatment:

Diagnostic Test: preload responsiveness

preload unresponsive

Description:

defined as an increase in Velocity time integral of the sub-aortic flow lower than 10%

Treatment:

Diagnostic Test: preload responsiveness