Cerebellar Alterations in Individuals With a Cannabis Use Disorder

Universitat Pompeu Fabra

Status: Completed

Conditions: Cannabis

Treatments: Behavioral: Explicit strategy; Behavioral: Visuo-motor rotation

Study type: Interventional

Funder types: Other

Identifiers

NCT02816034

CannabinoidsCerebellum

Details and patient eligibility

About

The purpose of this study is to investigate if individuals with a cannabis use disorder have an impaired cerebellar function by assessing possible alterations to their implicit adaptation during a visuomotor rotation task.

Enrollment: 32 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients diagnosed with a Cannabis use disorder following Diagnostic and Statistical Manual (DSM-V) criteria.
• Patients screen positive to cannabis in the urine analysis performed a week prior to assessment.
• Right-handed patients.
• Patients provide a signed consent.

Exclusion criteria

• Patients with another current substance use disorder (with the exception of tobacco).
• Patients with a visual impairment that has not been corrected.
• Patients with a cognitive impairment such as mental retardation.
• Patients with psychotic disorders.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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32 participants in 4 patient groups

Experimental Explicit

Experimental group

Description:

Cannabis user performs visuo-motor rotation tasks informed of an explicit strategy to maximise performance

Treatment:

Behavioral: Explicit strategy

Behavioral: Visuo-motor rotation

Control Explicit

Active Comparator group

Description:

Healthy subject performs visuo-motor rotation tasks informed of an explicit strategy to maximise performance

Treatment:

Behavioral: Visuo-motor rotation

Experimental Implicit

Experimental group

Description:

Cannabis user performs visuo-motor rotation tasks without being informed of the explicit strategy

Treatment:

Behavioral: Explicit strategy

Behavioral: Visuo-motor rotation

Control Implicit

Active Comparator group

Description:

Healthy subject performs visuo-motor rotation tasks without being informed of the explicit strategy

Treatment:

Behavioral: Visuo-motor rotation