Cerebellar Superficial Siderosis in Cerebral Amyloid Angiopathy (CSS)

Centre Hospitalier Universitaire de Nīmes

Status: Completed

Conditions: Siderosis; Cerebral Amyloid Angiopathy

Treatments: Other: None, pure observational study

Study type: Observational

Funder types: Other

Identifiers

NCT05394636

Local/2022/Dr-02

Details and patient eligibility

About

Cerebellar superficial siderosis (SS) has been recently reported to be present in about 10% of both hereditary (n=50) and sporadic (n=46) cerebral amyloid angiopathy (CAA) patients on 3T MRI using susceptibility-weighted imaging (SWI) in the majority of patients. In that study, cerebellar SS was associated with a higher number of supratentorial lobar and superficial cerebellar macrobleeds (although cerebellar SS was not directly located adjacent to these cerebellar macrobleeds). It is unclear if cerebellar SS is caused by in situ leakage of cerebellar leptomeningeal vessels or rather represents hemorrhagic diffusion from cerebellar parenchymal micro/macrobleeds or from supratentorial bleeding sources via the tentorium cerebelli (TC).

Enrollment: 111 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• CAA patients (according to the modified Boston criteria)
• with acute symptoms related to acute ICH, acute subarachnoid haemorrhage, or cortical SS

Exclusion criteria

• Patients with recent trauma,
• Patients with anticoagulation treatment,
• Patients with pathological blood coagulation tests (activated partial thromboplastin time [aPTT] ratio=patient's aPTT/normal control aPTT] >1.2; or partial thromboplastin time [PTT] <75%) or platelet count (<100 x 109/L)
• Patients with inflammatory CAA

Trial design

111 participants in 1 patient group

cerebral amyloid angiopathy (CAA)

Description:

Clinical and 1.5T MRI T2\*-weighted imaging characteristics analyses from sporadic probable CAA patients (according to the modified Boston criteria) presenting with acute symptoms related to acute ICH, acute subarachnoid haemorrhage, or cortical SS,

Treatment:

Other: None, pure observational study