Cerebellum - Cognitive Outcome and Functional Connectivity

Medical University of Vienna

Status: Completed

Conditions: Childhood Cerebellar Tumor

Study type: Observational

Funder types: Other

Identifiers

NCT01730274

cerebellum 1.1

KLI 252 (Other Grant/Funding Number)

Details and patient eligibility

About

Aim: To investigate the effect of cerebellar tumor surgery on the resting state functional connectivity level in higher order cognition networks known to interact with the cerebellum. Furthermore, to correlate the connectivity level of these networks with the neuropsychological performance and functional outcome of the patients.

The investigator's hypothesis is that the functional connectivity of various cognition networks in the cerebrum as assessed by resting-state functional magnetic resonance imaging can be impaired after cerebellar tumor surgery and can be correlated with the neuropsychological performance. The effect of surgery on the cognition networks and the neuropsychological performance is dependent on the tumor location within the cerebellum. Such a correlation seems feasible as functional connectivity analysis could be correlated with the neuropsychological impairment in various neuropsychiatric disorders. Furthermore, investigators were able to depict the maturation of the functional connectivity networks in parallel to the neurocognitive development in childhood

Enrollment: 31 patients

Sex: All

Ages: 15 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• • Male or female patients aged > 15 yrs

  • Age at surgery between 1 yrs - 12 yrs
  • Compliance (the patients have to be able to lay motionless in a 3 Tesla MR scanner and to cooperate with the examiner during the examination)
  • Signed informed consent from the patient and/or the parents

Exclusion criteria

• • Patients with Neurofibromatosis 1

  • Severe visual or auditory impairment
  • Cerebrospinal fluid shunt device
  • Prior radiotherapy or chemotherapy
  • Contraindications to MRI

Trial design

31 participants in 2 patient groups

patients

Description:

children operated on a cerebellar tumor

healthy subjects

Description:

healthy volunteers