Cerebral Antibiotics Distribution After Acute Brain Injury

Poitiers University Hospital

Status and phase: Completed; Phase 1

Conditions: Brain Injury; Bacterial Infection

Treatments: Drug: Ciprofloxacin; Drug: cefotaxime; Drug: Fosfocine; Drug: Metronidazole

Study type: Interventional

Funder types: Other

Identifiers

NCT01059890

A-BRAIN

Details and patient eligibility

About

The aim of the study is to explore the distribution of antibiotics in the brain after an acute brain injury because brain infections treatment is still an health care problem.

Enrollment: 18 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Acute brain injury
• Patient who receive an antibiotic for an infection or prophylaxy
• Glasgow coma score < 8

Exclusion criteria

• Age < 18 years old
• Pregnant woman
• HCV, HIV, HBV infection

Trial design

18 participants in 4 patient groups

Cefotaxime

Experimental group

Treatment:

Drug: cefotaxime

Metrodinazole

Experimental group

Treatment:

Drug: Metronidazole

Ciprofloxacine

Experimental group

Treatment:

Drug: Ciprofloxacin

Fosfocine

Experimental group

Treatment:

Drug: Fosfocine