Cerebral Blood Flow Effects of Resveratrol and Piperine in Humans

Northumbria University

Status: Completed

Conditions: Healthy

Treatments: Dietary Supplement: Trans- resveratrol; Other: Placebo (silica)

Study type: Interventional

Funder types: Other

Identifiers

NCT01331382

22AB2

Details and patient eligibility

About

Resveratrol is associated with a plethora of physiological effects in humans, including modulation of cerebral blood flow, despite apparently poor bioavailability. This study investigated whether the physiological effects of resveratrol could be affected when co-supplemented with piperine, an alkaloid which may be able to enhance the bioavailability of resveratrol.

Enrollment: 23 patients

Sex: All

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Between the ages of 18-35 years old
• Healthy
• Non-smoker

Exclusion criteria

• Not proficient in English
• Taking medication or herbal supplements
• Pregnant or breast feeding
• Heavy caffeine consumer
• History of head trauma, migraines, learning difficulties, ADHD, gastrointestinal problems.
• Food allergies of intolerances

Trial design

23 participants in 3 patient groups, including a placebo group

250mg trans- resveratrol

Experimental group

Treatment:

Dietary Supplement: Trans- resveratrol

Other: Placebo (silica)

250mg trans-resveratrol with 20mg piperine

Experimental group

Treatment:

Dietary Supplement: Trans- resveratrol

Other: Placebo (silica)

Placebo

Placebo Comparator group

Treatment:

Dietary Supplement: Trans- resveratrol

Other: Placebo (silica)