Cerebral Blood Perfusion Changes After General Anesthesia for Craniotomy

Fudan University

Status: Completed

Conditions: Surgery; Hyperemia; Brain Neoplasms

Treatments: Device: Transcranial Doppler (TCD); Procedure: Tumor removal surgery under general anesthesia; Procedure: jugular venous bulb catheterization; Procedure: Abdominal surgery under general anesthesia; Procedure: Radial artery catheterization

Study type: Interventional

Funder types: Other

Identifiers

NCT01642147

KY2012-183

Details and patient eligibility

About

Few studies look into cerebral blood flow (CBF) changes during emergence from general anesthesia for craniotomy. The purpose of this study is to demonstrate CBF changes during emergence from general anesthesia for craniotomy, through monitoring blood oxygen saturation of jugular vein bulb and transcranial Doppler.

Full description

30 patients undergoing selective craniotomy (craniotomy group) for supratentorial brain tumor removal and 30 patients undergoing selective abdominal surgery (abdominal surgery group) are planned to be enrolled in the study. Mean blood flow velocity in middle cerebral artery (Vmca), mean arterial pressure (MAP), blood oxygen saturation of jugular vein bulb (SjvO2) (only measured in craniotomy group)and arterial CO2 partial pressure (PaCO2) will be measured before general anesthesia, at tracheal extubation, and 30,60, 90, 120 min after extubation in both groups.

Enrollment: 60 patients

Sex: All

Ages: 25 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesia (ASA) physical status I or II
• Scheduled for selective supratentorial tumor removal surgery or major abdominal surgery.

Exclusion criteria

• Patients with evidence of systemic hypertension, intracranial hypertension, cerebrovascular diseases, other coexisting medical conditions likely to affect cerebral autoregulation.
• Preoperatively planned delayed tracheal extubation.
• Pregnant or nursing women

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 2 patient groups

Patients undergoing craniotomy

Experimental group

Description:

Patients undergoing craniotomy who are scheduled for selective supratentorial tumor removal surgery will be randomly chosen and recruited. Transcranial Doppler (TCD) measures,jugular venous bulb catheterization, radial artery catheterization, and tumor removal surgery under general anesthesia will be performed.

Treatment:

Procedure: Tumor removal surgery under general anesthesia

Procedure: jugular venous bulb catheterization

Procedure: Radial artery catheterization

Device: Transcranial Doppler (TCD)

Patients undergoing abdominal surgery

Active Comparator group

Description:

Randomly chosen patients undergoing selective abdominal surgery. Transcranial Doppler (TCD) measures,radial artery catheterization, and major abdominal surgery under general anesthesia will be performed.

Treatment:

Procedure: Abdominal surgery under general anesthesia

Procedure: Radial artery catheterization

Device: Transcranial Doppler (TCD)