Cerebral Bloodflow and Carbondioxide Reactivity During Mild Therapeutic Hypothermia in Patients After Cardiac Arrest

Radboud University Medical Center

Status: Unknown

Conditions: Post-Anoxic Encephalopathy; Cardiac Arrest

Study type: Observational

Funder types: Other

Identifiers

NCT00441753

KSCH0601

Details and patient eligibility

About

Survivors of a cardiac arrest frequently develop severe postanoxic encephalopathy. Derangements in cerebral blood after return of spontaneous circulation play an important role in the pathogenesis of postanoxic encephalopathy. In the present study we examine the effect of mild therapeutic hypothermia on cerebral blood flow and carbondioxide reactivity in patients after cardiac arrest.

Enrollment: 10 estimated patients

Sex: All

Ages: 18 to 95 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• adult patients
• GCS after return of circulation < 7
• Induced mild hypothermia for 24 hours
• primary rhythm ventricular fibrillation

Exclusion criteria

• Thrombolysis
• Cardiogenic shock with expected survival < 24 hrs
• Pregnancy
• No informed consent