Cerebral Dysfunction in Chronic ITPwith High Risk of Serious Bleeding Excluding Intracranial Hemorrhage.

A

Ain Shams University

Status

Unknown

Conditions

Chronic Thrombocytopenia

Treatments

Other: EEG,brain imaging
Other: IQ assessment and visual- motor assessment

Study type

Observational

Funder types

Other

Identifiers

NCT01764971
CNS and chronic ITP

Details and patient eligibility

About

Intracranial hemorrhage despite being rare, several chronic ITP patients experience moderate to severe behavioral problems including learning difficulties, memory affection .These changes could be due to the presence of minute capillary dysfunction

Full description

First identify the presence of cognitive, behavioral and/or minimal neurological deficit in patients with chronic ITP and correlate these changes with radiological evidence of minimal CNS bleeding. Second investigate the correlation between these behavioral and/or minimal neurological deficits and duration, site and severity of bleeding (a total of 200 patient of persistently low platelet count < 20x 10 9 for at least more than one month duration). The aim is to assess the behavioral changes in chronic ITP patients, and to assess the possible relation of such changes to duration and recurrence of very low platelet count as well as pattern of bleeding excluding frank intracranial hemorrhage.

Enrollment

100 estimated patients

Sex

All

Ages

4 to 18 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  1. Chronic ITP patients with persistent platelet count < 20 x 109/L for a period more than one month.
  2. Chronic ITP with more than one attack of wet purpura and OR internal bleeding.

Exclusion criteria

  1. Patients' with platelet count persistently more than 40 x 109/L.
  2. Past history of intracranial hemorrhage.
  3. Past history of known neurological or psychological deficit diagnosed before onset of ITP diagnosis

Trial design

100 participants in 2 patient groups

chronic itp and cerebral dysfunction
Description:
patients with chronic itp and had behavioral and or cognitive dysfunction
Treatment:
Other: IQ assessment and visual- motor assessment
Other: EEG,brain imaging
chronic itp only
Description:
chronic ITP patients without cerebral dysfunction
Treatment:
Other: IQ assessment and visual- motor assessment

Trial contacts and locations

1

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Central trial contact

yasmine I Elhenawy, lecturer

Data sourced from clinicaltrials.gov

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