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Cerebral Energy State in Cardiac Surgery

O

Odense University Hospital

Status

Completed

Conditions

Postoperative; Dysfunction Following Cardiac Surgery

Treatments

Procedure: Microdialysis

Study type

Interventional

Funder types

Other

Identifiers

NCT02846818
S-20130166

Details and patient eligibility

About

Impaired cerebral function remains an important complication of cardiopulmonary bypass (CPB) during cardiac surgery. The aim of the present study is to investigate whether the lactate to pyruvate (LP) ratio obtained by microdialysis (MD) of the cerebral venous outflow reflects a derangement of global cerebral energy state during cardiopulmonary bypass.

Full description

Patients undergoing primary, elective coronary artery bypass grafting were blindly randomized to usual range MAP (40 to 60 mmHg; n = 5) or intervention group MAP (60 to 80 mmHg; n = 5) during CPB. MD catheters were positioned in a retrograde direction in the internal jugular vein and a reference catheter was inserted into the brachial artery. The relations between LP ratio, MAP, data obtained from bi-frontal NIRS and neurological outcome measures were assessed.

Enrollment

10 patients

Sex

All

Ages

60+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Elective CABG on CPB

Exclusion criteria

  • Acute patients or reoperations
  • Patients with epidural catheter
  • Previous stroke
  • Stenotic carotids
  • Ejection fraction (EF) < 50 %
  • Estimated per operative risk > 5%

Trial design

Primary purpose

Diagnostic

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

10 participants in 2 patient groups

Low mean arterial perfusion pressure
Experimental group
Description:
5 patients undergoing primary, elective coronary artery bypass grafting were randomized to usual range MAP (40 to 60 mmHg) during CPB. Microdialysis catheters were positioned in a retrograde direction in the internal jugular vein.
Treatment:
Procedure: Microdialysis
High mean arterial perfusion pressure
Experimental group
Description:
5 patients undergoing primary, elective coronary artery bypass grafting were blindly randomized to intervention group MAP (60 to 80 mmHg) during CPB. Microdialysis catheters were positioned in a retrograde direction in the internal jugular vein.
Treatment:
Procedure: Microdialysis

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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