Cerebral Hemodynamics During Early Verticalization After (Successful) Thrombectomy Poststroke (CHEST)

University of Zurich (UZH)

Status: Unknown

Conditions: Healthy; Stroke

Treatments: Procedure: Verticalization

Study type: Observational

Funder types: Other

Identifiers

NCT04573114

2020-01732

Details and patient eligibility

About

This is a proof-of-concept study with a prospective observational design, where the association between progressive levels of verticalization and cerebral blood flow velocity (Ultrasound) in subacute stroke patients and healthy subjects will be investigated.

Enrollment: 80 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• First-ever ischemic stroke in the territory of the middle cerebral artery (MCA)
• ≤12 hours after mechanical thrombectomy
• Conscious
• Hemodynamically stable
• 18 years or older
• Informed consent of the patient and/ or legal representative

Exclusion criteria

• Verticalization not allowed according to treating physician
• Known pre-stroke disease affecting cerebral blood flow
• Temporal bone windows insufficient to enable ultrasound penetration
• Intubation anticipated or occurred
• Venous thromboembolism
• Symptomatic intracranial hemorrhage

Trial design

80 participants in 2 patient groups

Stroke subjects

Treatment:

Procedure: Verticalization

Healthy

Treatment:

Procedure: Verticalization