Cerebral Hemodynamics in Sleep Disorders

Yi Yang

Status: Completed

Conditions: Sleep Disorders, Intrinsic

Study type: Observational

Funder types: Other

Identifiers

NCT02752139

CHSD-01-R

Details and patient eligibility

About

The purpose of this study is to determine the relationship between sleep disorders and cerebral hemodynamics.

Full description

Sleep disorders continue to be the most unrecognized modifiable risk factor for stroke. The relationship between sleep disorders and vascular risk factors and stroke has been well-documented but not fully understood. The investigators hypothesize hemodynamics impairment to be its potential mechanism. It has been reported that sleep-related breathing disorder, a type of sleep disorders, contributed as a risk factor for stroke through hemodynamic and hematologic changes. The purpose of this study is to determine the relationship between different kind of sleep disorders and cerebral hemodynamics, including OSHAS, RLS, RBD, narcolepsy, etc. The dynamic cerebral auto-regulation (dCA) and Transcranial Doppler (TCD) will be used to evaluate cerebral hemodynamics.

Enrollment: 300 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• patients with sleep disorders
• meet the Diagnostic Criteria for Sleep Dyssomnias
• sufficient bilateral temporal bone windows for insonation of the MCA

Exclusion criteria

• middle cerebral artery (MCA) and/or other intracranial and/or extracranial major vascular 4 stenosis/occlusion, as diagnosed by a transcranial Doppler
• having a prior symptomatic cerebral vascular disease
• current arrhythmia, hyperthyroidism, anemia and unstable blood pressure, which may undermine hemodynamic stability
• inability to cooperate sufficiently to complete the dCA examination

Trial design

300 participants in 2 patient groups

patients with sleep disorders

normal individuals without sleep disorders