Cerebral Microembolism in the Critically Ill With Acute Kidney Injury (COMET-AKI)

Insel Gruppe AG, University Hospital Bern

Status: Terminated

Conditions: Cerebral Embolism

Treatments: Device: Renal replacement therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT02621749

199/2015

Details and patient eligibility

About

The primary objective of this study is to investigate the impact of continuous renal replacement therapy and intermittent renal replacement therapy on microbubble / cerebral microemboli generation in a cohort of critically ill patients with dialysis-dependent acute kidney injury.

Enrollment: 66 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• > 18 yrs.
• Signed IC

Exclusion criteria

• Heart disease (PFO, ASD, VSD, severe valvular disease)
• Atrial fibrillation
• Cerebrovascular pathology
• Missing temporal bone window
• Allergy to plastic contained in the investigative device (transcranial Doppler)
• Chronic kidney disease
• Pregnancy
• Participation in another study

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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66 participants in 2 patient groups

CRRT group

Active Comparator group

Description:

the CRRT group receives continuous renal replacement therapy for acute kidney injury

Treatment:

Device: Renal replacement therapy

IRRT group

Active Comparator group

Description:

the IRRT group receives intermittent renal replacement therapy after termination of CRRT.

Treatment:

Device: Renal replacement therapy