Cerebral Oxygen Monitoring During Surgery and Recovery After Surgery in Patients Having Lung Surgery

Mount Sinai Health System

Status: Terminated

Conditions: Cerebral Oxygen Desaturation

Study type: Observational

Funder types: Other

Identifiers

NCT01835327

GCO 12-1398

HS#: 12-00716

Details and patient eligibility

About

The current study proposes to address the question of whether patients' cerebral oxygen saturation levels are predictive of their recovery from thoracic surgery. Further, the study poses the hypothesis that a patient's poor recovery status goes on to increase a patient's risk of developing post-operative morbidities such as pneumonia, arrhythmias and delirium. The aim of this study is to address the observation that some patients struggle more than others in their recovery and that 1) this may be a result of intraoperative cerebral oxygen desaturations and 2) that this may affect their post-operative morbidity. If a potential means of predicting poor outcomes is identified this will lead to further research into how to adjust the associated variables, such as cerebral oxygenation, to improve patient post-operative outcome.

Full description

Despite advances in the field of thoracic surgery, post-operative morbidity continues to be a significant problem with limited understanding of the connection between the insult of surgery and anesthesia and the pathophysiology of the development of these morbidities. Surgeons in the thoracic department have noted that some patients seem to recover less vigorously than other patients. What accounts for these different recovery trajectories is unclear. Researchers have developed a Post-Operative Quality Recovery Scale (PQRS) which assesses six domains (physiologic, nociceptive, emotive, activities of daily living, cognitive, and overall patient experience) and has been suggested to serve as a means of tracking patients' recovery from surgery.

Enrollment: 130 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• speak English
• 18 yo or older
• willing to participate
• undergoing thoracic surgery at Mount Sinai Hospital that will require one lung ventilation

Exclusion criteria

• prisoners
• lack capacity to consent to trial

Trial design

130 participants in 2 patient groups

Exposed

Description:

Cerebral oximetry desaturation below 65% for a minimum of 3 minutes

Not Exposed

Description:

Those patients who do not experience a cerebral oxygen desaturation below 65% for a minimum of 3 minutes