Cerebral Perfusion in Hypothermic Circulatory Arrest

Insel Gruppe AG, University Hospital Bern

Status: Completed

Conditions: Cerebrovascular Circulation

Treatments: Diagnostic Test: Measurement of tissue oxygenation index (TOI)

Study type: Observational

Funder types: Other

Identifiers

NCT03484104

2017-02216

Details and patient eligibility

About

Selective antegrade cerebral perfusion (sACP) during aortic arch surgery in hypothermic circulatory arrest (HCA) is an established method for intraoperative neuroprotection. Although sACP is established as a beneficial method to reduce secondary neurological side effects due to brain-malperfusion, there are several parameters like sACP flow rate, perfusion pressure or temperature of the perfusate, where the optimal values remain unclear. The flow rate of the sACP-perfusate is increased according to center-specific standard-procedures. The optimal sACP flow rate, monitored by near infrared spectroscopy (NIRS), is to be investigated in this single center clinical prospective observational study. 40 Patients are enrolled over an estimated period of 14 months.

Enrollment: 40 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 18 years or older
• Elective cardiac surgery with cardiopulmonary bypass
• Hypothermic circulatory arrest
• General informed consent signed

Exclusion criteria

• Severe stenotis in cerebral arteries

Trial design

40 participants in 1 patient group

Hypothermic circulatory arrest

Description:

Patients undergoing cardiac surgery with hypothermic circulatory arrest and selective antegrade cerebral perfusion

Treatment:

Diagnostic Test: Measurement of tissue oxygenation index (TOI)