Cerebral Prophylactic Irradiation With Saving Hippocampus and Amygdala (IPC)

Centre Francois Baclesse, Luxembourg

Status: Terminated

Conditions: Non Small Cell Lung Cancer

Treatments: Radiation: Irradiation prophyllactique cérébrale

Study type: Observational

Funder types: Other

Identifiers

NCT03209128

IPC

Details and patient eligibility

About

Hippocampus and amygdala are parts of the brain involved in the recognition of emotions, memories, memory, language ... It is therefore very important to protect them during irradiation of the brain.

The aim of this study is to evaluate cerebral irradiation with saving hippocampus and amygdala protects these brain functions in patients with small cell lung cancer (SCLC) Radiotherapy of the brain

Enrollment: 11 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients over 18 years of age
• Patients with a limited SCLC demonstrated histologically responsive or stable to radiochemotherapy or patients with a histologically proven extended SCLC responding to chemotherapy.
• WHO Performance Index 0-1 and / or Karnovsky Index> 70
• Possibility of long-term monitoring

Exclusion criteria

• Concomitant chemotherapy
• Impossibility of performing an MRI or CT without injection
• Presence of cerebral metastases
• History of cerebral irradiation at any time
• Patient suffering from severe collagenosis
• Patient with cognitive disorders with MMSE score <24

Trial design

11 participants in 1 patient group

Irradiation prophyllactique cérébrale

Treatment:

Radiation: Irradiation prophyllactique cérébrale