Cerebral Pulsatility Index Compared To Mean Arterial Blood Pressure Guided Protocol In Sepsis Induced Encephalopathy:

Tanta University

Status: Completed

Conditions: Encephalopathy; Norepinephrine; Sepsis

Treatments: Other: Mean arterial blood pressure guided protocol; Other: Transcranial doppler pulsatility index guided protocol

Study type: Interventional

Funder types: Other

Identifiers

NCT05842616

35559/6/22

Details and patient eligibility

About

The aim of our study is to compare between transcranial doppler pulsatility index and mean arterial blood pressure in guiding management of sepsis induced encephalopathy.

Full description

Sepsis induced encephalopathy is the most frequent sepsis related organ dysfunction. It appears early during the course of infection, often before any other organ involvement in up to 70% of hospitalized septic patients and is associated with significant change of cerebral circulation caused by redistribution of blood flow during sepsis that accompanies the abnormal inflammatory response during an infection, in absence of direct central nervous system involvement.

Enrollment: 112 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients aged 18 years or older
• Must had clinical diagnosis of sepsis induced encephalopathy.

Exclusion criteria

• Refusal to participate in the study.
• Cerebral infection.
• Known cerebral lesions (Neoplasm, Traumatic brain injury, Stroke, Ischemic or hemorrhagic cerebrovascular lesions, high intracranial pressure).
• Known severe carotid stenosis (>70％).
• Intoxication due to drugs.
• Pregnancy.
• Patients supported by intra-aortic balloon pumb (IABP).

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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112 participants in 2 patient groups

Transcranial doppler pulsatility index guided protocol

Experimental group

Description:

Norepinephrine titration that will be guided by Transcranial doppler (TCD) pulsatility index.

Treatment:

Other: Transcranial doppler pulsatility index guided protocol

Mean arterial blood pressure guided protocol

Active Comparator group

Description:

Norepinephrine titration that will be guided by Mean arterial blood pressure (MAP).

Treatment:

Other: Mean arterial blood pressure guided protocol