Cerebral Regional Oxygen Saturation and Markers of Brain Damage During Primary Hip Arthroplasty

Military Institute od Medicine National Research Institute

Status: Completed

Conditions: Arthroplasty, Hip Replacement; Delirium, Dementia, Amnestic, Cognitive Disorders

Treatments: Device: cemented or cementless type of hip prothesis

Study type: Interventional

Funder types: Other

Identifiers

NCT02342236

06101968-3

Details and patient eligibility

About

Postoperative Cognitive Disorders (POCD) are common in hospitalized people > 60 year old, especially in orthopedic patients. Etiology of POCD is complex, and in some aspects still remains unclear. The role of thromboembolic events in etiology of POCD was discussed. The incidence of such events in patients who underwent big joints arthroplasty can be as high as 40 to 60%, although some cases are subclinical. Thromboembolic material can block a blood flow through a vessels in the brain. As a consequence cerebral neurons can be damaged or destroyed. After neuronal damage specific substances, such as S100B protein, glial fibrillary acidic protein (GFAP) and neuron-specific enolase (NSE) are released to the blood. The serum concentrations of these biomarkers can be measured. Moreover, the block of blood flow will decrease regional cerebral saturation in affected parts of the brain.

In this project the authors would like to analyze the correlation between the regional cerebral saturation and serum concentration of both S100B protein and GFAP in orthopedic patients scheduled to primary hip arthroplasty.

Enrollment: 18 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patient scheduled to primary hip arthroplasty,
• orthopedic procedure under spinal anesthesia.

Exclusion criteria

• patients younger than 18 y.o.,
• surgery under general anesthesia,
• patients who refused to participate in the study.

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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18 participants in 2 patient groups

cemented

Other group

Description:

Primary hip arthroplasty with bone cement use.

Treatment:

Device: cemented or cementless type of hip prothesis

cementless

Other group

Description:

Primary hip arthroplasty without bone cement use.

Treatment:

Device: cemented or cementless type of hip prothesis