Cerebral Reorganization in Schizophrenia

University of Konstanz

Status: Completed

Conditions: Schizophrenia

Treatments: Behavioral: Treatment as usual; Behavioral: Facial Affect Training- FAT; Behavioral: Brain Fitness & Brain Training- Posit Science

Study type: Interventional

Funder types: Other

Identifiers

NCT01781000

RO805/142

Details and patient eligibility

About

The purpose of this study is to reveal the specific effects of computer-aided cognitive training on cerebral reorganization in schizophrenia

Full description

Impairment in cognitive functions is one of the main symptoms in schizophrenia and is currently one of the challenges in the treatment of the disease. In this study we compare effects of two computer-aided training programs. One focused on auditory perception and processing as a basic ability underlying higher order information processing. The other training focus on facial affect discrimination and working memory. Both trainings are computer-aided and time-intensive, including up to twenty sessions within four weeks.

Enrollment: 80 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of schizophrenia and disorders with psychotic features
• Intact auditory perception
• Intact visual perception

Exclusion criteria

• Mental retardation
• Age over 60
• Insufficient German language knowledge

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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80 participants in 3 patient groups

Auditiory verbal discrimination training

Experimental group

Description:

Brain Fitness \& Brain Training- Posit Science

Treatment:

Behavioral: Brain Fitness & Brain Training- Posit Science

Facial affect discrimination training

Experimental group

Description:

Behavioral: Facial Affect Training- FAT

Treatment:

Behavioral: Facial Affect Training- FAT

Treatment as usual

Active Comparator group

Description:

standard treatment/rehabilitation protocol of schizophrenia ward

Treatment:

Behavioral: Treatment as usual