Cerebral Small Vessel Disease Registry Study

Bin Cai

Status: Enrolling

Conditions: Cerebral Small Vessel Diseases

Study type: Observational

Funder types: Other

Identifiers

NCT04318119

MRCTA,ECFAH of FMU [2019]245

Details and patient eligibility

About

The aim of this study is to determine the clinical spectrum and natural progression of Cerebral Small Vessel Disease (CSVD) and in a prospective multicenter study, to assess the clinical, genetic and epigenetic features of patients with CSVD, , to find independent imaging markers, and to optimize clinical management.

Enrollment: 3,000 estimated patients

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Sign informed consent.
2. Age>18
3. At least one of the following CSVD MRI characteristics: ①recent small subcortical infarct;②lacune of presumed vascular origin;③white matter hypertensity of presumed vascular origin;④perivascular space;⑤cerebral microbleeds;⑥brain atrophy

Exclusion criteria

1. Unable to cooperate with inspectors
2. Non-vascular white matter lesions
3. Other cognitive diseases (such as alzheimer's disease, Parkinson's disease or thyroid disease)
4. Serious systemic illness, such as heart, liver, kidney disease or major mental illness
5. Contraindications for imaging examination