Cerebrospinal Fluid Movements Through Interventricular Foramina in Phase Contrast Magnetic Resonance Imaging (PC-MRI) (MLCSFIV)

Centre Hospitalier Universitaire de Besancon

Status: Completed

Conditions: Mri; CSF Circulation Disorder; Foramen; Monro, Obstruction

Treatments: Device: MRI

Study type: Interventional

Funder types: Other

Identifiers

NCT04145414

P/2019/425

Details and patient eligibility

About

Assess the reproductibility of PC-MRI for cerebrospinal fluid movements through the interventricular foramina on volunteer subjects.

Full description

It is a monocentric interventional prospective study. Each subject will have to pass two MRI. Phase contrast MRI (PC-MRI) will be calibrated for each subject by assessing the optimal encoding velocity. Three sequences including the aqueduct and the two interventricular foramina (IVF) will be done. The signal will be analysed by syngo.via software after defining by two different investigators the region of interest (ROI) which correspond to the IVF or the aqueductal lumen. Descriptive statistics will test the intra-individual and inter-observer consistency based on 4 flow parameters.

Enrollment: 28 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Mini-Mental State Examination score > 28/30

Exclusion criteria

• MRI contraindication
• Medical or surgical history related to following pathologies: nervous system disease, cardiac arrhythmia, cardiac or respiratory insufficiency.
• Long-term medical treatment
• Ongoing pregnancy

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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28 participants in 1 patient group

Cerebral magnetic resonance imaging x2

Experimental group

Description:

Cerebral MRI performed at enrolment visit and at +6 weeks (maximum)

Treatment:

Device: MRI