Cerebrospinal Fluid Proteom in Dependence of Intranasal Breast Milk (NAMU)

University Hospital of Cologne

Status: Unknown

Conditions: Hydrocephalus in Infants

Treatments: Other: no intervention

Study type: Observational

Funder types: Other

Identifiers

NCT04229693

UHC_NAMU

Details and patient eligibility

About

Investigation of the cerebrospinal fluid proteom in preterm infants with posthemorrhagic hydrocephalus in our neonatology center with analysis for modulation of proteom in dependence of breastmilk feeding and way of application such as via gavage tube, oral or nasal application.

Full description

Since the nasal route might be highly effective for neurotrophins and other growth factors the cerebrospinal fluid will be investigated using mass spectrometry to identify modulating effects of intranasal breast milk application on the cerebrospinal fluid proteom.

Enrollment: 20 estimated patients

Sex: All

Ages: 3 days to 12 months old

Volunteers: No Healthy Volunteers

Inclusion criteria

• preterm infant with hydrocephalus and regular drainage

Exclusion criteria

• Inborn error of metabolism