Cerebrovascular Autoregulation During and After Liver Transplantation (dARICULtx)

Johannes Gutenberg University (JGU)

Status: Unknown

Conditions: Liver Failure; Encephalopathy, Hepatic; Cerebrovascular Disorders

Treatments: Other: No interventions

Study type: Observational

Funder types: Other

Identifiers

NCT01597102

837.041.10 III

Details and patient eligibility

About

The cerebrovascular autoregulation (AR) is impaired in patients with hepatic encephalopathy. Patients with the indication to liver transplantation mostly have mild to severe hepatic encephalopathy. Transplantation should recover the encephalopathy. The aim of the study is to investigate the AR during liver transplantation, with the questions if the AR is impaired at the beginning of surgery and if there are changes in AR. For follow up the AR will be measured at the first days after transplantation at the ICU.

Full description

The cerebrovascular autoregulation (AR) will be measured using transcranial doppler and calculating the index of autoregulation Mx. This measurement is continuous with online calculation. So, the possible changes over the whole time of surgery can be detected. Furthermore, the measurement of AR at the ICU will be performed daily at the same time over a measurement period of 60 Minutes and the time course of AR after liver transplantation will be described.

Enrollment: 20 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• liver transplantation
• age > 18 years

Exclusion criteria

• sepsis
• preexisting cerebral diseases
• traumatic brain injury
• pregnancy

Trial design

20 participants in 1 patient group

Liver transplantation

Description:

Patients with liver failure and liver transplantation

Treatment:

Other: No interventions