Cerebrovascular Autoregulation in Sepsis, Influence of Renal Replacement Therapy (SepsAR2)

Johannes Gutenberg University (JGU)

Status: Withdrawn

Conditions: Severe Sepsis; Septic Shock

Treatments: Procedure: continuous veno-venous hemodialysis

Study type: Observational

Funder types: Other

Identifiers

NCT01926301

83743712

Details and patient eligibility

About

The cerebrovascular autoregulation is impaired in patients with severe sepsis and septic shock. A continuous veno-venous hemodialysis may improve impaired cerebrovascular autoregulation.

Hypothesis: continuous hemodialysis recovers impaired cerebrovascular autoregulation in patients with acute severe sepsis and septic shock.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• severe sepsis or septic shock
• adult patients
• possibility of transcranial Doppler ultrasound

Exclusion criteria

• traumatic brain injury
• known cerebrovascular diseases
• Infection of the brain
• chronic renal failure
• pregnancy

Trial design

0 participants in 2 patient groups

Hemodialysis

Description:

Patients with severe sepsis or septic shock with acute renal failure and requirement of continuous veno-venous hemodialysis

Treatment:

Procedure: continuous veno-venous hemodialysis

No hemodialysis

Description:

Patients with severe sepsis or septic shock without acute renal failure and no requirement of continuous veno-venous hemodialysis