Cerebrovascular Dysregulation in Chronic Kidney Disease

University of North Texas, Denton, TX

Status: Completed

Conditions: Chronic Kidney Diseases

Treatments: Behavioral: Stretching; Behavioral: Exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT05571605

IRB # 22-305

Details and patient eligibility

About

The purpose of this study is to test whether or not regular exercise training may improve brain blood flow regulation in patients with chronic kidney disease (CKD).

Full description

Prior research has shown that CKD patients have an increased risk of stroke and that impairments in brain blood flow regulation predict stroke in other chronic disease states. This study will test whether exercise training can improve brain blood flow regulation via improved dynamic cerebral autoregulation and cerebrovascular carbon dioxide reactivity in CKD. Participants will undergo exercise training on a stationary bicycle, or stretching exercises, 3 times per week for 12 weeks.

Enrollment: 11 patients

Sex: All

Ages: 30 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Individuals with chronic kidney disease stages III-IV.

Exclusion criteria

• Heart failure
• Chronic obstructive pulmonary disease
• Uncontrolled hypertension or hypotension
• Pregnancy or plans to become pregnant
• Inability to exercise on a stationary bicycle
• Current participation in exercise more than 20 minutes twice per week

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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11 participants in 2 patient groups, including a placebo group

Exercise Training

Experimental group

Description:

Participants will exercise 3 times a week on a stationary bicycle. Exercise intensity will begin at low levels (50% of maximal heart rate reserve) and increase as tolerated to a maximum of 80% of maximal heart rate reserve. Exercise time will progress from an initial 20 minutes per session to a maximum of 45 minutes per session.

Treatment:

Behavioral: Exercise

Stretching

Placebo Comparator group

Description:

Participants will undergo progressive whole body stretching and balance exercises. This type of low intensity exercise is designed not to increase heart rate but rather to improve joint mobility and the ability to perform activities of daily living. This will serve as the control group to the exercise group. The control group will come in for stretching sessions 3 times per week for 20-45 minutes.

Treatment:

Behavioral: Stretching