Cerebrovascular Hemodynamics in Patients With ARDS.

Universitätsklinikum Hamburg-Eppendorf

Status: Completed

Conditions: ARDS

Treatments: Diagnostic Test: Near-infrared spectroscopy-based assessement of cerebral autoregulation.

Study type: Observational

Funder types: Other

Identifiers

NCT03949738

CAR ARDS

Details and patient eligibility

About

The acute respiratory distress syndrome (ARDS) is a life-threatening disease with functional impairment of the lung. It is characterized by an excessive inflammatory response of lung tissue, capillaries, and blood vessels and is associated with high mortality. Patients who survive the acute phase of this critical disease often suffer from long-term physical, psychological, and mental sequelae, as well as persistent cognitive deficits.

In healthy individuals, autoregulatory mechanisms of the intracranial blood vessels keep blood supply to the brain independent of fluctuations in systemic blood pressure. In the case of a serious illness, these mechanisms of autoregulation may be impaired, which may favor cerebral hypoperfusion. Impairment of cerebrovascular hemodynamics can lead to neuronal damage in short and long term.

The aim of this project is to investigate cerebrovascular autoregulation in adult patients with ARDS and to evaluate the cognitive outcome at 3, 6 and 12 months after discharge from the intensive care unit.

Enrollment: 66 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ARDS

Exclusion criteria

• Pre-existing neurological diseases with known intracranial pathology
• Cerebrovascular disorders, including hemodynamically relevant extracranial vascular stenoses

Trial design

66 participants in 1 patient group

Adult patients with ARDS

Description:

Adults patients fulfilling the Berlin criteria for ARDS

Treatment:

Diagnostic Test: Near-infrared spectroscopy-based assessement of cerebral autoregulation.