Cerebrovascular Response to Acute Exercise

University of Wisconsin (UW)

Status: Completed

Conditions: Healthy; Physical Activity

Treatments: Other: Control; Other: Aerobic Exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT03722953

2018-0783

Protocol Version 10/23/2018 (Other Identifier)

A176000 (Other Identifier)

EDUC/KINESIOLOGY (Other Identifier)

Details and patient eligibility

About

Cerebrovascular function and peripheral vascular function will be measured in healthy young adults, before and after acute bouts of aerobic exercise at various intensities.

Full description

Acute bouts of aerobic exercise have been shown to enhance vascular reactivity of the peripheral circulation; however, the effects of a single exercise session on the cerebral circulation are unknown. This study will measure cerebrovascular function and peripheral vascular function before and after aerobic exercise at high and low intensities.

The research aims are:

1. To determine if a single bout of aerobic exercise acutely enhances cerebrovascular function
2. To determine the effect of aerobic exercise intensity and dose on cerebrovascular function in healthy adults.
3. To determine if the acute exercise-induced changes in cerebrovascular function are associated with acute exercise-induced changes in peripheral vascular function in healthy adults.

Enrollment: 18 patients

Sex: All

Ages: 20 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Between 20-40 years old
• BMI < 30 kg/m2
• Recreationally active
• Experience running on a treadmill

Exclusion criteria

• Current smoker
• History or evidence of: hepatic disease, renal disease, hematological disease, cardiovascular disease, stroke/neurovascular disease, diabetes
• Taking blood pressure medication
• History of depression or other mood related disorders
• Part of a vulnerable population (e.g. pregnant women, prisoner, individuals lacking capacity to consent, etc.)

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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18 participants in 1 patient group

Aerobic Exercise

Other group

Description:

Control: Cerebrovascular function and peripheral vascular function will be measured. Aerobic Exercise: Across four separate visits, participants will perform light intensity exercise, light intensity exercise plus an additional task, vigorous intensity exercise and vigorous intensity exercise to match the energy expenditure of light intensity exercise visit.

Treatment:

Other: Aerobic Exercise

Other: Control