Cervical Cancer Screening Strategies

Lei Li

Status: Enrolling

Conditions: Cervical Cytology; Cancer Screening; Human Papillomavirus Infection; Cervical Intraepithelial Neoplasia; Cervical Cancer

Study type: Observational

Funder types: Other

Identifiers

NCT05309122

EVUCC

Details and patient eligibility

About

This study is to investigate retrospectively the results of cervical cytology and high-risk human papillomavirus in the past 20 years recorded in Peking Union Medical College Hospital. The histological findings after cervical cancer screening were reviewed. The diagnostic values of different screening strategies were compared based on the results of cervical histology. The primary endpoint is the diagnosis of grade 2 cervical intraepithelial neoplasia (CIN2) or more severe lesions (CIN2+). The secondary endpoints include following objectives: (1) the invasive procedures needed according to the screening results; (2) the diagnosis of vaginal and/or vulval intraepithelial neoplasia; (3) the persistence and recurrence of human papillomavirus infection; and (4) the cost-effectiveness of screening strategies for CIN2+.

Enrollment: 10,000 estimated patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Aged 18 years or older
• With definite cervical histology after cervical cancer screening, ore with at least one screening test after first testing

Exclusion criteria

• Not meeting all of the inclusion criteria