Cervix Hypoxia FAZA

University Health Network, Toronto

Status

Active, not recruiting

Conditions

Cervix Cancer

Treatments

Procedure: 18F-Fluoroazomycin Arabinoside (18F-FAZA)

Study type

Interventional

Funder types

Other

Identifiers

NCT01549730

UHN REB 11-0026-C

Details and patient eligibility

About

The purpose of this study is to look for low levels of oxygen (hypoxia) in your cervix cancer using a special x-ray test called a positron emission tomography (PET)scan. Hypoxia may have an effect on how cervix cancer grows and responds to treatments like radiotherapy and chemotherapy. Doctors at Princess Margaret Hospital have measured hypoxia in over 300 patients. The use of PET scans to measure hypoxia may be better and simpler than the methods used previously.

Enrollment

30 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age ≥18 years
Histologic diagnosis of squamous cell carcinoma, adenocarcinoma or adenosquamous carcinoma of the cervix
TNM (7th edition) cT1-4, N0-1, M0-1
Intention to treat using radiotherapy with or without concurrent cisplatin chemotherapy according to the current treatment policies of the PMH Gynecology Group
No cytotoxic anti-cancer therapy for cervix cancer prior to study entry
A negative urine or serum pregnancy test within the two week interval immediately prior to PET-CT imaging, in women of child-bearing age
Ability to provide written informed consent to participate in the study

Exclusion criteria