Cetylated Fatty Acid for Reducing Pain After TKA

Thammasat University

Status: Enrolling

Conditions: Postoperative Pain; Postoperative Inflammation

Treatments: Drug: cetylated fatty acid; Drug: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT06300008

OrthoTU13

Details and patient eligibility

About

To compare efficacy of cetylated fatty acid with placebo for reducing postoperative pain after unilateral TKA. The hypothesis is topical cetylated fatty acid can mitigate postoperative pain after TKA.

Enrollment: 80 estimated patients

Sex: All

Ages: 50 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 50-80 years
• Osteoarthritic knee patients underwent unilateral primary TKA
• Participants understand and consent to the protocol of the trial

Exclusion criteria

• Inflammatory knee arthritis
• Previous knee surgery or trauma
• Previous knee infection
• Skin problem around the knee such as eczema, psoriasis, wound infection
• Allergy to studied drug

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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80 participants in 2 patient groups, including a placebo group

cetylated fatty acid

Experimental group

Description:

Topical cetylated fatty acid, apply 2 times/day for 6 weeks after operation

Treatment:

Drug: cetylated fatty acid

Placebo

Placebo Comparator group

Description:

Topical placebo, apply 2 times/day for 6 weeks after operation

Treatment:

Drug: Placebo