Change in Airway Responsiveness After Allergen Exposure

University of Saskatchewan

Status: Completed

Conditions: Allergic Asthma

Treatments: Drug: Methacholine Chloride; Drug: Mannitol

Study type: Interventional

Funder types: Other

Identifiers

NCT01699594

BioReb #10-227 (Other Identifier)

IIS-A-524

Details and patient eligibility

About

Exposure to allergens changes the way the airway responds to some stimuli (methacholine). The investigators will look at whether or not exposure to allergens changes the way the airway responds to a different stimuli (mannitol) and compare that with the known stimuli (methacholine).

Enrollment: 11 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• mild, allergic asthma
• FEV1 greater than 70% predicted
• methacholine PC20 less than or equal to 16mg/ml

Exclusion criteria

• known sensitivity to mannitol or other excipient
• diagnosis of any other respiratory or non respiratory disease/disorder that would preclude the individual from participating
• recent thoracic, abdominal or eye surgery
• recent allergen exposure (4 weeks), respiratory infection (6 weeks)
• current immunotherapy
• pregnancy
• history of anaphylaxis
• use of asthma therapies other than short acting beta agonist

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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11 participants in 2 patient groups

Mannitol

Experimental group

Description:

This arm will assess the allergen induced change in airway responsiveness to mannitol bronchoprovocation.

Treatment:

Drug: Mannitol

Methacholine Chloride

Active Comparator group

Description:

This arm will assess the allergen induced change in airway responsiveness to methacholine bronchoprovocation.

Treatment:

Drug: Methacholine Chloride