Change in MAPSE During Treatment of Sepsis

University of Maryland Baltimore (UMB)

Status: Enrolling

Conditions: Sepsis

Treatments: Other: Treatment of Sepsis

Study type: Observational

Funder types: Other

Identifiers

NCT05634733

HP-00102983

Details and patient eligibility

About

Patients with bloodstream infections (sepsis) have been found in prior studies to have infection-related heart dysfunction, even if they did not have preexisting heart problems. Factors related to the infection may cause the heart to not pump as well as it should, causing critical illness in the form of low blood pressure (shock) and heart failure. Ultrasound is frequently used in the emergency department to evaluate why a patient might have low blood pressure. Part of that evaluation may include obtaining ultrasound images and making measurements about how well or poorly the heart is pumping. The investigators will evaluate a certain measurement that relates to cardiac function, determine how it changes in patients before and after they are treated for septic shock. This will involve placing an ultrasound probe on the patient's chest, measuring the upward and downward movement of the mitral valve, the mitral annulus systolic plane excursion (MAPSE), and comparing the measurements before and after treatment is started. The investigators are attempting to determine if this measurement improves before and after treatment.

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of Sepsis or Septic Shock

Exclusion criteria

• Age equal to or less than 17
• patient in the emergency department
• Unable to perform POCUS exam due to medical necessity
• Patients without sepsis
• unable to obtain consent or have a legal representative consent

Trial design

50 participants in 1 patient group

Patients with Sepsis

Description:

These are patients who present to the emergency department with sepsis. They will have a MAPSE at the time of enrollment and then after initial treatment.

Treatment:

Other: Treatment of Sepsis