Change in Taste Sensation After Orthognathic Surgery

Yağmur Malkoc

Status: Completed

Conditions: Altered Taste; Orthognathic Surgery

Treatments: Diagnostic Test: Localized taste tests; Diagnostic Test: Whole mouth taste tests

Study type: Interventional

Funder types: Other

Identifiers

NCT06103422

IstanbulMUH-DF-YM-01

Details and patient eligibility

About

Orthognathic surgery refers to jaw operations that can be performed on the upper jaws (Le Fort I osteotomy) and lower jaws (Sagittal Split Ramus osteotomy). In orthognathic surgery practice, taste perception could be affected by potential damage to peripheral nerves that conduct chemosensory information regarding gustation from the palate and tongue. This study aimed to evaluate the changes in the sense of taste after Le Fort I osteotomy, Sagittal Split Ramus osteotomy, and bimaxillary surgery.

Full description

The subjects were orthognathic surgery patients with facial skeletal deformities who applied to the Department of Oral and Maxillofacial Surgery. Thirty-five patients, aged 17-42 years, gustatory functions were evaluated by administering localized taste tests and whole mouth taste tests preoperatively and at postoperative 1st, 3rd, and 6th months. In the tests, solutions containing sucrose for a sweet taste, sodium chloride for a salty taste, citric acid for a sour taste, and quinine hydrochloride for a bitter taste were used. Patients were compared between the operation group they were in and between operation groups.

Enrollment: 35 patients

Sex: All

Ages: 17 to 42 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• dentofacial deformity
• American Society of Anesthesiologists category 1 or 2

Exclusion criteria

• zinc, iron, and/or vitamin deficiencies
• oncological, neurological, endocrinological, and rheumatological diseases
• chronic drug use due to systemic disease
• smokers
• history of chemotherapy and radiotherapy to the head and neck region, orthognathic surgery, maxillofacial trauma, and damage to the nerves related to the taste sensation

Trial design

Primary purpose: Screening

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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35 participants in 2 patient groups

Streaming of patients and administration of tests

Experimental group

Description:

35 patients who met the inclusion criteria were divided into surgical groups. Patients with indications for upper jaw surgery were divided into Le Fort I operation, patients with lower jaw surgery were divided into Sagittal Split Ramus operation, and double jaw surgery groups. Localized taste tests and whole-mouth taste tests were applied to the patients.

Treatment:

Diagnostic Test: Whole mouth taste tests

Diagnostic Test: Localized taste tests

Repetition of tests at certain intervals

Experimental group

Description:

Gustatory functions were evaluated by administering localized taste tests and whole mouth taste tests preoperatively and at postoperative 1st, 3rd, and 6th months.

Treatment:

Diagnostic Test: Whole mouth taste tests

Diagnostic Test: Localized taste tests