Change in the Phase III Slope of the Volumetric Capnography by Prone Positioning in Acute Respiratory Distress Syndrome

Istanbul University - Cerrahpasa (IUC)

Status: Enrolling

Conditions: Respiratory Failure; Ventilation Perfusion Mismatch; Acute Respiratory Distress Syndrome

Treatments: Procedure: Prone Positioning

Study type: Observational

Funder types: Other

Identifiers

NCT05535543

05072022-3605

Details and patient eligibility

About

This study evaluates the effects of prone positioning on homogenization of ventilation.

Full description

After initiation of mechanical ventilation and assessing the eligibility of the patient, informed consent will be taken from the closest kin. If eligible, following steps will be performed which are part of standard ARDS patient care.

1. Low-flow Pressure Volume curve and assessment of airway opening pressure
2. Calculation of recruitment to inflation ratio
3. Optimizing Positive End-Expiratory Pressure

Afterwards, phase III slope of the patient will be recorded at four timepoints:

Supine 1 (immediately before turning to prone position) Prone 1 (immediately after prone position) Prone 2 (at the end of the 16-24 hour prone cycle) Supine 2 (immediately after turning to supine position)

Enrollment: 60 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ARDS criteria met
• intubated and mechanically ventilated as a result of respiratory failure
• PaO2/FiO2 <200

Exclusion criteria

• age older than 18
• Chronic pulmonary disease, pneumothoraces, intraabdominal hypertension (> 12 mmHg), pregnancy, not expected to survive >24 hours, hemodynamic instability

Trial design

60 participants in 1 patient group

Baseline slope of phase iii

Description:

Severe ARDS patients who are intubated and mechanically ventilated and will undergo prone positioning

Treatment:

Procedure: Prone Positioning