Changes in Adrenal Hormones During Adrenal Radiofrequency Ablation

Mie University

Status and phase: Completed; Phase 3; Phase 2

Conditions: Adrenal Tumors

Treatments: Procedure: Radiofrequency ablation

Study type: Interventional

Funder types: Other

Identifiers

NCT00997594

No secondary IDs

274

Details and patient eligibility

About

The purpose of this study is to evaluate changes in adrenal hormones during adrenal radiofrequency (RF) ablation.

Full description

Adrenal radiofrequency (RF) ablation has been increasingly used for the treatment of unresectable adrenal tumors. But one of the major complication is a increase in blood pressure. Hormonal release during RF ablation is considered the cause of hypertension. But there has been no evidence that adrenal hormones affects changes in blood pressure. In this prospective study, we evaluate the changes in adrenal hormones during RF ablation and clarify the cause of hypertensive crisis.

Enrollment: 18 patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Unresectable adrenal tumor which will be treated by radiofrequency (RF)ablation
• Blood pressure is 140mmHg or less before RF ablation
• Age of 20-years or more
• Performance status of 0 or 1
• Agreement from the patient

Exclusion criteria

• Platelet count of 50,000/mm^3 or International normalized ratio (INR)>1.5

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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18 participants in 2 patient groups

Adrenal radiofrquency (RF) ablation

Active Comparator group

Description:

Patients who wll receive adrenal RF ablation.

Treatment:

Procedure: Radiofrequency ablation

Abdominal RF ablation other than adrenal gland

Active Comparator group

Description:

Patients who will receive abdominal radiofrequency ablation other than adrenal gland.

Treatment:

Procedure: Radiofrequency ablation